Panther Fusion® AdV/hMPV/RV Assay
Expanded respiratory targets for patient-specific testing.
Overview
Documents
Training
Leverage the flexibility of mini-panels to personalize patient testing.
Adenoviruses (AdV), human Metapneumovirus (hMPV) and rhinoviruses (RV) can cause some of the most common respiratory illnesses across all age groups, ranging from the common cold to pneumonia, bronchitis and croup.1-3 They can also exacerbate several respiratory diseases, such as asthma and COPD4, making timely diagnosis and treatment critical for symptom management.1-3 The Panther Fusion® AdV/hMPV/RV assay detects and differentiates AdV, hMPV and RV infections on a fully automated system for rapid results that aid informed care decisions.5
Broad Identification
The Panther Fusion AdV/hMPV/RV assay is designed to detect the many strains of AdV, hMPV and RV.5
Highly Specific, Highly Sensitive
The sensitivity of the Panther Fusion AdV/hMPV/RV assay is up to 98.7% and the specificity is up to 99.3%, depending on the virus.†5
Get Results On Demand
With a run time of < 3 hours, the Panther Fusion® system can deliver same-day results to help inform timely treatment decisions.6
One Sample, Multiple Insights
Our complete menu of multiplexed assays allows your lab to personalize patient testing. Process a single sample on the Panther Fusion® system with any combination of assays to distinguish overlapping signs and symptoms of common respiratory viruses. Customize seasonal respiratory testing, year-round, on a fully automated platform.
Aptima® SARS-CoV-2 Assay*
Aptima® SARS-CoV-2/Flu A/B Assay*
Panther Fusion® Flu A/B/RSV Assay
Panther Fusion® AdV/hMPV/RV Assay
Panther Fusion® Paraflu Assay
Panther Fusion® SARS-CoV-2 Assay*
Panther Fusion® SARS-CoV-2/Flu A/B/RSV Assay
Sample Type
Nasopharyngeal swab
Collection Devices
Universal Transport Media (UTM)
Viral Transport Media (VTM)
Throughput
Run 1 assay or over 1,000 assays in 24 hours
The Panther Fusion® System:
An All-In-One Solution
- Manage high- and low-volume throughput on one system. Scale up testing when needed – utilizing the available capacity on your Panther Fusion® system.
- Increase output per shift. Process up to 1,000 Panther Fusion® samples in 24 hours, without increasing staff.7
- Set it and forget it. Increase your walk-away time and increase efficiency with random and continuous access, and bi-directional LIS, on a fully automated system.
- Simplify processing and minimize waste. Reduce hands-on time with ready-to-use Panther Fusion® reagent cartridges. Each Cartridge can run 12 tests and has 60-day onboard stability.5
Ordering Information
*The Aptima SARS-CoV-2, Panther Fusion SARS-CoV-2 and Aptima SARS-CoV-2/Flu assays have not been FDA cleared or approved: These tests have been authorized by FDA under an EUA for use by authorized laboratories; The Aptima and Panther Fusion SARS-CoV-2 assays have been authorized only for the detection of nucleic acid from SARS-CoV-2, not for any other viruses or pathogens; The Aptima SARS-CoV-2/Flu assay has been authorized only for the simultaneous qualitative detection and differentiation of nucleic acid from SARS-CoV-2, Flu A virus, Flu B virus, and not for any other viruses or pathogens. The Aptima SARS-CoV-2, Panther Fusion SARS-CoV-2, and Aptima SARS-CoV-2/Flu assays are only authorized for the duration of the declaration that circumstances exist justifying the authorization of emergency use of in vitro diagnostic tests for detection and/or diagnosis of COVID-19 under Section 564(b)(1) of the Act, 21 U.S.C. § 360bbb-3(b)(1), unless the authorization is terminated or revoked sooner.
†Sensitivity information provided above is specific to hMPV analyte. For complete performance characteristics relative to reference testing for the analytes of the Panther Fusion AdV/hMPV/RV assay, please refer to the package insert.
1. Clinical Overview. CDC. http://www.cdc.gov/adenovirus/hcp/clinical-overview.html. 2. Rhinoviruses. CDC. https://www.cdc.gov/ncird/rhinoviruses-common-cold.html. 3. Human Metapneumovirus (HMPV). CDC. https://www.cdc.gov/ncird/human-metapneumovirus.html#symptoms. 4. Britto et al., 2017. Respiratory Viral Infections in Chronic Lung Diseases. Clin Chest Med 38 (2017) 87–96. 5. Panther Fusion AdV/hMPV/RV assay. US package insert AW-28996. Hologic, Inc.; 2023 6. Panther/Panther Fusion System Operator’s Manual. AW-26055. Hologic, Inc.: 2022. 7. Data on File.http://dx.doi.org/10.1016/j.ccm.2016.11.014
Safety Data Sheets
Package Inserts
Overview
Package Inserts
Resources
Syndromic Respiratory Testing.
Patient-Specific Results.
The Panther Fusion Respiratory assays are the premier set of assays on the Panther Fusion® system. You can provide truly personalized syndromic respiratory testing with qualitative detection and differentiation of the most common respiratory viruses from a single patient sample. Each Panther Fusion Respiratory assay can be processed independently or simultaneously with other Panther Fusion® and Aptima® assays.
The Panther Fusion® SARS-CoV-2/Flu A/B/RSV, Panther Fusion® Flu A/B/RSV, Panther Fusion® Paraflu, Panther Fusion® AdV/hMPV/RV and Panther Fusion® Bordetella assays comprise the CE-IVD respiratory testing menu on the fully automated Panther Fusion system. Each is a multiplex, real-time PCR in vitro diagnostic test. These assays can be run on nasopharyngeal (NP) swab specimens obtained from individuals exhibiting signs and symptoms of a respiratory tract infection.1-5 Additionally, the Panther Fusion® SARS-CoV-2 assay has received Emergency Use Authorization for the detection of SARS-CoV-2 from nasopharyngeal, nasal, mid-turbinate and oropharyngeal swab specimens, nasopharyngeal wash/aspirate or nasal wash, and lower respiratory tract specimens.6
Personalized Respiratory Testing
The Panther Fusion assays provide the flexibility to run patient-specific targets, allowing for personalized patient testing and better cost control in your lab.
- The Panther Fusion® SARS-CoV-2/Flu A/B/RSV assay§ - Qualitative detection and differentiation of SARS-CoV-2, influenza A virus, influenza B virus and respiratory syncytial virus.1
- The Panther Fusion® Flu A/B/RSV assay - Qualitative detection and differentiation of influenza A virus, influenza B virus and respiratory syncytial virus.2
- The Panther Fusion® AdV/hMPV/RV assay - Qualitative detection and differentiation of adenovirus, human metapneumovirus and rhinovirus.3
- The Panther Fusion® Paraflu assay - Qualitative detection and differentiation of parainfluenza 1 virus, parainfluenza 2 virus, parainfluenza 3 virus and parainfluenza 4 virus.4
- The Panther Fusion® Bordetella assay† - Qualitative detection and differentiation of Bordetella pertussis and Bordetella parapertussis.5
- The Hologic® SARS-CoV-2 assays*‡ - Qualitative detection of SARS-CoV-2 virus.6-8
Flex Your Ability
With the Panther Fusion Respiratory assays, a single patient specimen can be tested for SARS-CoV-2 as well as other common respiratory viruses which present with overlapping symptoms, boosting efficiency and increasing clinical insight.
Additionally, when you leverage the power of Panther Fusion, your lab can:
- Run more efficiently with full automation from sample-to-result.
- Receive easy-to-interpret results.
- Personalize syndromic respiratory testing by processing multiple assays from a single specimen.
- Control costs by running only the required assays and reduce expense of unnecessary tests.
- Eliminate the need for reagent preparation with Panther Fusion’s ready-to-use format.
- Reduce waste with 60 day on-board reagent stability.
- Consolidate menu onto a single, fully automated platform with the ability to run both Aptima and Panther Fusion assays alongside each other at the same time.
Resources
Education
* The Aptima SARS-CoV-2, Panther Fusion SARS-CoV-2 and Aptima SARS-CoV-2/Flu assays have not been FDA cleared or approved: These tests have been authorized by FDA under an EUA for use by authorized laboratories; The Aptima and Panther Fusion SARS-CoV-2 assays have been authorized only for the detection of nucleic acid from SARS-CoV-2, not for any other viruses or pathogens; The Aptima SARS-CoV-2/Flu assay has been authorized only for the simultaneous qualitative detection and differentiation of nucleic acid from SARS-CoV-2, Flu A virus, Flu B virus, and not for any other viruses or pathogens. The Aptima SARS-CoV-2, Panther Fusion SARS-CoV-2, and Aptima SARS-CoV-2/Flu assays are only authorized for the duration of the declaration that circumstances exist justifying the authorization of emergency use of in vitro diagnostic tests for detection and/or diagnosis of COVID-19 under Section 564(b)(1) of the Act, 21 U.S.C. § 360bbb-3(b)(1), unless the authorization is terminated or revoked sooner.
†The Panther Fusion Bordetella Assay is TGA approved and CE marked, it is not Health Canada approved.
‡The Panther Fusion SARS-CoV-2 Assay is Health Canada and TGA approved, it is not CE marked.
§The Panther Fusion SARS-CoV-2/Flu A/B/RSV Assay is CE marked, it is not Health Canada or TGA approved. In development and not for sale in the U.S.
References: 1. Panther Fusion SARS-CoV-2/Flu A/B/RSV assay. Package insert AW-25328. Hologic, Inc.; 2022. 2. Panther Fusion A/B/RSV assay. Package insert AW-16162 Hologic, Inc.; 2018. 3. Panther Fusion AdV/hMPV/RV assay. Package insert AW-16164. Hologic, Inc.; 2019. 4. Panther Fusion Paraflu assay. Package insert AW-16163. Hologic, Inc.; 2018. 5. Panther Fusion Bordetella assay. Package insert AW-18637. Hologic, Inc.; 2018. 6. Panther Fusion SARS-CoV-2 assay. Package insert AW-21388. Hologic, Inc.; 2021. 7. Aptima SARS-CoV-2 assay. US package insert AW-21492-001. Hologic, Inc.; 2021. 8. Panther Fusion SARS-CoV-2/Flu assay. US package insert AW-22364. Hologic, Inc; 2021.
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